Missed Pregnancy: Why It Happens and What to Do Next?

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Missed (non-progressing) pregnancy is a condition where the development of the embryo or fetus stops, usually without obvious signs in the early stages. According to statistics, this situation occurs in about 10% of all clinically diagnosed pregnancies. It is a difficult experience — both physically and emotionally. But it is very important to know: you are not to blame.

Why does a missed pregnancy happen?

There can be many reasons, and they often combine. The main ones include:

Genetic abnormalities of the fetus — the most common cause in the first trimester. Nature “stops” the development of an embryo with severe chromosomal disorders incompatible with life.
Hormonal disorders — for example, progesterone deficiency or thyroid dysfunction. These conditions can be identified even before pregnancy and corrected in time.
Infections — TORCH complex, STIs (sexually transmitted infections), viral or bacterial diseases can negatively affect implantation and fetal development.
Immunological factors, such as antiphospholipid syndrome (APS) — when the mother’s body mistakenly perceives the embryo as a “threat.”
Uterine anatomical features — septa, fibroids, adhesions can physically interfere with proper embryo attachment.
Placental problems that impair access to oxygen and nutrients.
Toxic factors — smoking, alcohol, drugs, as well as working with chemicals or radiation exposure.
Chronic maternal diseases, such as uncontrolled diabetes, hypertension, autoimmune conditions, anemia.
Severe stress, emotional or physical exhaustion — rarely a cause on their own, but can complicate the course of pregnancy.
Age — risks increase after 35–40 years, especially for chromosomal abnormalities.

Statistics:

Under 30 years old — 1 in 10 pregnancies may end in miscarriage
Aged 35 to 39 — up to 2 in 10
Over 45 — more than 5 in 10

What’s important to know?

You are not alone. Almost always, a missed pregnancy is not related to your actions. It is not your fault.
This is not a sentence. One missed pregnancy does not mean the problem will recur.
After repeated cases (2 or more), it is important to undergo a full examination of both partners. In many cases, the cause can be identified and resolved.

Modern options after a missed pregnancy: what can medicine offer today?

Today, medicine has made great strides in understanding and addressing the causes of missed pregnancy. Thanks to a comprehensive approach, we can significantly reduce the risk of recurrence and help patients give birth to a healthy baby.

1. Comprehensive diagnostics for both partners

After two or more miscarriages, extended examination is recommended:

Karyotyping of both partners — allows detection of chromosomal rearrangements that cause no symptoms in parents but may lead to pregnancy loss.
Hormonal profile analysis (progesterone, estradiol, TSH, prolactin, LH, FSH, androgens)
Ovarian reserve assessment (AMH, ultrasound)
Immunological testing — to rule out antiphospholipid syndrome (APS), detect autoimmune processes
Infectious screening — TORCH infections, STIs
Uterine examination (ultrasound, hysteroscopy, MRI) to assess anatomical features

2. Preimplantation Genetic Testing (PGT-A/PGT-M)

For couples who have experienced pregnancy loss due to genetic causes, modern reproductive medicine offers a solution:

IVF with PGT-A — embryos are tested for chromosomal number and structure before transfer. This allows excluding embryos with abnormalities that may lead to missed pregnancy.
PGT-M — in case of suspected hereditary diseases.

It is not a guarantee, but it significantly increases the chances of successful pregnancy on the first attempt.

3. Medical preparation for pregnancy

In our clinic, we use individualized care protocols:

Endometrial preparation, correction of hormonal profile
Progesterone support
Low-dose aspirin or heparin (if indicated)

Correction of immunological causes of miscarriage
Correction of comorbid conditions (hypothyroidism, diabetes, anemia, APS)

4. Psychological support

Pregnancy loss is not only a medical but also a deeply emotional event. In our clinic, women have access to psychological support, which helps to reduce fears, relieve guilt, and prepare for a new attempt with hope and confidence.

We are with you at every step.

Loss is painful, but it’s not the end. In our clinic, we combine modern science, experience, and humanity to help you go through this journey and give yourself a chance at the happiness of parenthood.

Booking a consultation is the first step toward taking control and a new beginning.
We’re here for you, and we know how to help.