10th International IVIRMA Congress

At the end of spring, we participated in the scientific event 10th International IVIRMA Congress, dedicated to the most important trends in reproductive medicine.

Part one.

Main ideas:

• Personalized (with an individual approach to each specific couple and situation) medicine is cheaper and effectively shortens the time until the birth of a healthy child in the family
• The DuoStim stimulation program (double stimulation) within one menstrual cycle significantly shortens the path to obtaining of an euploid (chromosomally healthy) embryo
• The number of obtained euploid embryos obtained from the fertilization of eggs in the second phase of the cycle in the double stimulation program is compared to the obtaining of embryos from the fertilization of oocytes in the first phase of the cycle
• The results in obtaining the number of euploid embryos in the Freeze all program, if we start the stimulation of follicle growth from any day of the menstrual cycle, completely coincide with the effectiveness of obtaining euploid embryos in the stimulation started from the second day of the menstrual cycle
• The achievements and techniques of stimulation of superovulation to preserve oocytes in patients with oncology before the start of chemotherapy, techniques of preservation of ovarian tissue in case of impossibility of stimulation were discussed
• Currently, even more genetic causes and new “candidate” genes have been identified for premature ovarian reserve reduction POI – (premature ovarian insufficiency)
• The influence of ovarian reserve (РOI) on the general state of the female body and management strategies of women with such a diagnosis were discussed. Potential diseases of the female body, which are associated with a premature decrease in the ovarian reserve
• The data on the use of ASCOT, PRP, Bone marrow derived stem cells for obtaining the optimal number of quality eggs with premature reduction of the ovarian reserve were given
• Data on the potential capabilities of artificial intelligence AI (Artificial Intelligence) in the selection of drugs to stimulate the growth of follicles, optimal dosage, determination of the day of obtaining oocytes were presented. As well as the assessment of embryo development using artificial intelligence and the prediction of the selection of embryos for transfer with the highest probability of the correct set of chromosomes (euploidy).
• Data based on calculations of how many hours of exposure to progesterone are optimal for embryo transfer into the uterine cavity (ET) are given.

Part Two:

• Understanding the deeper mechanisms of embryo implantation. What is the receptive endometrium with successful implantation?
• The results of the methodology and algorithms for the use of PRP in thin endometrium for the purpose of preparation for embryo transfer into the uterine cavity (ET)
• Important data were provided that a thin endometrium affects not only the effectiveness of implantation, but also the carrying of a pregnancy (increasing the risks of preeclampsia in pregnant women, premature maturation of the placenta, and premature birth)
• The influence of the importance of the female microbiome (healthy microflora) on the success of implantation and bearing, methods of improving the microflora
• To date, it has been proven that the treatment of chronic endometritis includes not only the use of antibiotic therapy, but also the systemic improvement of healthy microflora
• The influence of endometriosis on the effectiveness of IVF programs, the data of the algorithm of preparation for embryo transfer into the uterine cavity (ET) with widespread adenomyosis were discussed
• The optimal age for saving (freezing) oocytes in the “Delayed Motherhood” program is 33 years; The duration of preservation of vitrified (frozen) oocytes does not affect birth rate of children. Only the reproductive age at which the oocytes were obtained and the number of mature M II eggs (optimally 20) affect the effectiveness of the Delayed Motherhood program in the future.
• A comparison was made of the cost of saving oocytes in European countries depending on the reproductive age, the opportunities provided by vitrification at a young age
• The possibilities of artificial intelligence AI (Artificial Intelligence) in estimating AMH, FSH, reproductive age, a woman’s weight in calculating the required number of eggs, the amount of stimulation at the stages that are necessary for the birth of a healthy child in the family.
• The use of follitropin delta in the stimulation of superovulation, the new paradigm of fertility in the world from 2010-2020, the average age of fertility when using vitrified oocytes
• Data on the results of the level (percentage) of mosaic embryos were given, depending on the level of work of the genetic laboratory and the level of embryologists in the clinic.
• Santiago Munne provided data on the efficiency of embryo euploidy assessment in comparison of non-invasive PGT and data obtained after biopsy of the trophectoderm of embryos.
   
  This event demonstrates that modern technologies give us more and more opportunities to achieve the main goal – preserving the possibility of motherhood and the birth of healthy children in families.