Platelet-rich plasma (PRP), whose therapeutic value is equal to that of stem cells, is currently one of the most promising therapeutic agents in regenerative medicine. It is increasingly used in various fields of medicine, including aesthetic dermatology, orthopedics, sports medicine, surgery, dentistry, and obstetrics and gynecology.Over the years, PRP has been used to treat a wide variety of injuries and conditions.
As far back as the early 1940s, doctors were using “embryonic extracts” to promote wound healing. It was a substance rich in growth factors and cytokines – active proteins that contribute to the growth, proliferation and differentiation of cells, and also regulate intercellular and intersystem interactions in the body.
Later it turned out that platelets are able to secrete a large number of different growth factors and cytokines, as well as other bioactive substances – chemokines, which promote tissue regeneration. Thus, the therapeutic effect of using PRP consists in the local delivery of biologically active molecules that accelerate healing and tissue regeneration.The treatment involves taking a small amount of venous blood from the patient, followed by its processing in a centrifuge to separate platelets from other blood components that are not needed for regeneration. As a result, a natural biological product with a high concentration of platelets and a content of active substances 3-5 times higher than in plasma is obtained. This resulting concentration of platelets and growth factors is injected directly into the injured area.
Advantages of PRP:
✓ minimally invasive procedure
✓ promotes tissue regeneration and rejuvenation
✓ increases collagen production
✓ acts as a “biological glue” that promotes tissue healing
✓ causes cell differentiation
✓ does not cause allergies
✓ practically has no contraindications and side effectsThe widespread use of PRP in regenerative medicine has prompted researchers around the world to apply its potential in other areas of medical science. These efforts were also implemented in obstetrics and gynecology.
✓ promotes tissue regeneration and rejuvenation
✓ increases collagen production
✓ acts as a “biological glue” that promotes tissue healing
✓ causes cell differentiation
✓ does not cause allergies
✓ practically has no contraindications and side effectsThe widespread use of PRP in regenerative medicine has prompted researchers around the world to apply its potential in other areas of medical science. These efforts were also implemented in obstetrics and gynecology.
To date, works have been published on the successful use of PRP therapy in caesarean sections, in the field of reproductive medicine, in particular in Asherman syndrome (formation of adhesions (adhesions) in the uterine cavity), cases of thin endometrium, premature ovarian failure and poor ovarian response to stimulation, auxiliary treatment of recurrent genitourinary fistula, etc.The greatest effectiveness of the use of PRP in gynecology was shown in the treatment of atrophic changes of the mucous membranes of the genital organs, stress urinary incontinence and overactive bladder.
PRP therapy is ideal for women who want to enjoy younger looking skin or healthier mucous membranes at any age.
PRP injections can be considered an effective alternative to corticosteroids for the treatment of vulvovaginal autoimmune conditions such as Lichen Sclerosus. Also, PRP may be useful in the adjunctive treatment of chronic radiogenic wounds after radiation therapy.The use of regenerative medicine approaches continues to grow, but a large number of clinical studies are needed to definitively prove the clinical efficacy of the method and to standardize it.08:42
PRP injections can be considered an effective alternative to corticosteroids for the treatment of vulvovaginal autoimmune conditions such as Lichen Sclerosus. Also, PRP may be useful in the adjunctive treatment of chronic radiogenic wounds after radiation therapy.The use of regenerative medicine approaches continues to grow, but a large number of clinical studies are needed to definitively prove the clinical efficacy of the method and to standardize it.08:42