Table of contents
This conference was truly inspiring — practical, modern, and full of new data and solutions for improving IVF outcomes.
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PPOS + AI — a simple protocol without antagonist injections
PPOS is a modern alternative to classical stimulation.
Instead of daily injections to prevent premature ovulation, progesterone tablets are used.Advantages:
- Fewer injections
- More convenient and comfortable
- A safe and effective protocol, especially in oocyte or embryo freezing programs.
Suitable for women planning embryo transfer later or in complex clinical cases.
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PERFORM – what is it and why is it important?
PERFORM is a large European study that investigated how to correctly select hormone doses for ovarian stimulation in IVF.
It studied a specific combination of two hormones: FSH and LH. It was found that this combination:
- helps retrieve more oocytes,
- improves embryo quality,
- increases chances of pregnancy.
This protocol is especially effective for women with low ovarian reserve or over the age of 35.
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Progesterone support of the luteal phase (LPS)
- Serum progesterone level (P) ≥ 9.2 ng/mL on the day of embryo transfer — OPR (ongoing pregnancy rate) was 53% with adequate progesterone vs 32% with lower levels.
- Recommendation: monitor progesterone levels before embryo transfer + personalize LPS in FET cycles (treat progesterone level below 9.2 ng/mL as the cut-off).
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BMI and harmful habits
- BMI ≥ 25 → lower progesterone levels with the same LPS dose → reduced implantation rates.
- Smoking and alcohol → oxidative stress and decreased embryo quality.
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Strategy for thin endometrium — when EMT < 7 mm
ESHRE recommends:
- Optimize estrogen support (transdermal, oral);
- Add PRP or granulocyte colony-stimulating factor (G‑CSF) for intrauterine infusion (data still limited);
- Perform hysteroscopy in case of suspected synechiae and to rule out chronic endometritis.
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Our presentation from Reprolife Clinic: “The impact of platelet-rich plasma on oocyte yield and blastocyst development in IVF patients undergoing DuoStim protocol”
Main findings:
- Comparison before and after PRP in DuoStim (double stimulation in two phases of the menstrual cycle):
- Increased number of fertilized oocytes;
- Increased total number of blastocysts;
- Increased number of good-quality blastocysts;
- PRP application in DuoStim showed significant improvement in the second stimulation cycle.
This presentation adds strong evidence for the effectiveness of intraovarian PRP in DuoStim protocols.
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AI for predicting implantation and preeclampsia
The Carlos Simon Foundation received awards for their AI models for early prediction of implantation and preeclampsia — a new level of reducing uncertainty.
Practical takeaways:
- Pergoveris + personalization: r‑hFSH:LH ≥150 IU → more oocytes, higher effectiveness.
- PPOS + AI: reduces the number of injections during stimulation.
- LPS monitoring: progesterone ≥9.2 ng/mL before embryo transfer → individualized dosing.
- Thin endometrium: optimized estrogen + PRP/G‑CSF + hysteroscopy.
- PRP in DuoStim: improves maturity and quality of blastocysts.
Lifestyle: BMI, harmful habits — critically important for success.
ESHRE 2025 is all about smart personalization in treatment, AI-powered decisions, innovations (like PRP), and supporting every couple. It’s not just a conference — it’s a testament to love for the profession and life.
